Neuroanatomy 1 — The Brain

Early development

formation of the neural tube:  neural groove and neural folds

cranial expansions [vesicles]

prosencephalon [forebrain]

mesencephalon [midbrain]

rhombencephalon [hindbrain]

flexures

cephalic

pontine

cervical

ventricles

development of the vesicles

forebrain

olfactory bulbs [rhinencephalon]

cerebral hemispheres [telencephalon]

optic vesicles

diencephalon

pineal body

infundibulum

mesencephalon

tectum [forms optic lobes in lower vertebrates]

corpora quadrigemina

hindbrain

cerebellum

pons

medulla oblongata

[metencephalon + myelencephalon]

Development of the skull

formation of the cranial vault bones
    frontal
    parietal
    temporal
    occipital
    sphenoid
    ethmoid

craniosynostosis

neonatal skull development

The meninges

dura mater

epidural space

periosteal dura

meningeal dura

subdural space

arachnoid

subarachnoid space

pia

The whole brain

Brain stem 1

medulla oblongata

fourth ventricle

inferior velum forms its roof

ascending and descending tracts

inferior cerebellar peduncles (restiform bodies)

decussation of the pyramids

respiratory, vasomotor, cardiac centers

nuclei for cranial nn IX–XII

olivary nuclei [relay centers between cerebral cortex/basal nuclei and cerebellum]

reticular formation

pons

floor of the fourth ventricle

pontine nuclei

middle cerebellar peduncles

nuclei for cranial nn V–VIII

reticular formation

corticospinal, corticobulbar, and corticopontine tracts

Mesencephalon

midbrain [mesencephalon]

cerebral aqueduct (aqueduct of Sylvius)

cerebral peduncles

nuclei for cranial nn III–IV and anterior part of V

red nucleus and rubrospinal tract

superior cerebellar peduncle

corpora quadrigemina

superior colliculi [visual, auditory, tactile reflex centers]

inferior colliculi [auditory reflex centers]

Cerebellum 2, 6

anatomy

peduncles

superior (brachia conjunctiva)... midbrain

middle (brachia pontis)... pons

inferior (restiform body)... medulla oblongata

cerebellar hemispheres

vermis

cerebellar cortex

folia cerebelli

fissures

arbor vitae

layers

outer molecular layer [input]

Purkinje cell layer [output]

to deep cerebellar and lateral vestibular nuclei

inner granular layer [input]

functional considerations

functions quickly with no storage

coordination of somatic motor activity

regulation of muscle tone

maintenance of equilibrium

lesions

do not result in paralysis

ataxia 3

hypotonia 4 and asthenia

tremors and nystagmus 5

ipsilateral representation

Forebrain

diencephalon

rostral limit is the interventricular foramina (foramina of Monro)

third ventricle

lateral walls are the thalami

intermediate mass [variable, ~60%]

roof is the epithalamus

floor is the hypothalamus

thalamus

major sensory center

crude, uncritical consciousness [the reptilian brain]

epithalamus

choroid plexus and the production of cerebrospinal fluid (CFS)

pineal body

posterior commissure where it joins midbrain

hypothalamus

optic chiasm

infundibulum

from tuber cinereum

mammillary bodies

functions

regulation of body temperature, metabolism, sleep, emotions, sexual drive

integrated with endocrine system

Cerebrum

topology

hemispheres

longitudinal fissure

corpus callosum

surfaces

dorsolateral

inferior

medial

poles

frontal

occipital

temporal

convolutions

gyri

sulci

five lobes

frontal lobe

inferior frontal gyrus

speech center (Broca’s area):  Brodmann area 44

precentral gyrus

primary motor cortex:  Brodmann area 4

central sulcus (fissure of Rolando)

parietal lobe

postcentral gyrus

somatesthetic cortex:  Brodmann areas 1–3

lateral sulcus (Sylvian fissure)

temporal lobe

primary auditory center:  Brodmann 7  area 41 8, 9
secondary centers:  Brodmann areas 42, 22

insula

occipital lobe

calcarine sulcus

visual area:  Brodmann area 17

parietooccipital sulcus

sulcus cinguli parallels corpus callosum

gyrus cinguli:  smell association

collateral sulcus inferiorly

hippocampal gyrus lies medial

uncus:  smell & taste appreciation

cortex

primary cortex

association areas

white matter

association tracts

short association fibers

long association fibers

commissural tracts

corpus callosum

anterior and posterior commissural tracts

projection tracts

ascending [afferent] mostly from thalamus

descending [efferent]

corona radiata → corticospinal tracts

basal nuclei ( basal ganglia ) 10

striatum

putamen, caudate nucleus, nucleus accumbens

claustrum, amygdaloid nucleus, substantia nigra, &
globus pallidus [putamen + globus pallidus = lentiform nucleus]

subthalamic nuclei

internal capsule [between caudate and lentiform nuclei]

external capsule [outside of lentiform nucleus]

claustrum [lies lateral to external capsule]

conditions linked with basal-nuclei dysfunction:

Ventricles of the brain

fourth ventricle

choroid plexus

capillaries are part of pia, but covered with ependymal cells

production of CSF

median aperture (foramen of Magendie)

lateral aperture (foramina of Luschka)

hydrocephalus

cerebral aqueduct (aqueduct of Sylvius)

lies within mesencephalon

third ventricle

choroid plexus

interventricular foramina (foramina of Monro)

lateral ventricles

septum pellucidum

central portion

choroid plexus

anterior, posterior, and inferior horns

arachnoid villi of the superior sagittal sinus

Meninges of the brain

dura mater

periosteal dura

meningeal dura

falx cerebri

superior and inferior sagittal sinuses

tentorium cerebelli

transverse and superior petrosal sinuses

straight sinus

falx cerebelli

occipital sinus

diaphragma sellae

arachnoid

subdural space

subarachnoid space

arachnoid trabeculae

over the gyri, pia + arachnoid = leptomeninx

cisterns

arachnoid villi

pia mater

Blood supply to the brain

common carotid a

external carotid a

internal carotid a

enters carotid canal

posterior communicating a

ophthalmic a

anterior cerebral a

middle cerebral a

subclavian a

internal thoracic a

thyrocervical trunk

costocervical trunk

vertebral a

through transverse processes of superior six cervical vertebrae

spinal branches

anterior spinal a

cerebellar branches

posterior inferior cerebellar a

anterior inferior cerebellar a

forms basilar a

posterior cerebral aa

circle of Willis (circulus arteriosus cerebri)

R posterior cerebral a → R posterior communicating a →
R internal carotid a → R anterior cerebral a →
anterior communicating a → L anterior cerebral a →
L internal carotid a → L posterior communicating a →
L posterior cerebral a → basilar a bifurcation →
R posterior cerebral a → ...

Questions for thought
1.   Make a diagram showing the three primary brain vesicles. Name each and using clinical terminology, name the resulting adult brain regions and briefly define a function for each.
2.   Describe the basal nuclei, being sure to include their functions.
3.   Describe the role of the cerebellum in maintaining smooth, coordinated motor activity. Give some examples of the effects of lesions to the cerebellum.
4.   What is the reticular formation? And what does it do?
5.   Describe the blood supply to the brain; be sure to indicate the formation and significance of the circle of Willis.
6.   How is cerebrospinal fluid produced and drained? What are the paths of its circulation?
7.   Sue develops a blood clot that blocks the right branch of the middle cerebral a, a blood vessel that supplies the anterior portior of the right cerebral hemisphere. What symptoms would you expect to observe as a result of this blockage?
Other questions to test your knowledge

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