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Lunar PIXImus


Academic and pharmaceutical researchers commonly use the mouse for investigations of genetics, cellular physiology, and of agents affecting bone or soft-tissue composition. Bone and tissue composition measurement using dual-energy x-ray absorptiometry (DEXA) densitometry eliminate the need for destructive chemical analysis - a time- and labor-consuming process that requires days or weeks to complete. DEXA densitometry allows the researcher the opportunity to make multiple measurements in situ during the life of the animal - providing true longitudinal measures. Unfortunately, the spatial resolution of table DEXA densitometers is too poor for mice and the rectilinear scanning process of older peripheral DEXA densitometers require as much as 30 minutes for a total body acquisition with relatively poor precision and spatial resolution. The long process requires careful sedation techniques and often endangers animal safety. The Lunar PIXImus Densitometer (GE Medical Systems) provides bone mineral and body composition results from total body imaging in less than 5 minutes. Fast imaging allows faster access to important data and is safer on animals.

The PIXImus allows automated, accurate and precise measurement of bone and tissue for small animals 10-50 g (e.g., mice, lemmings). These bone, fat and lean measurements exhibit excellent correlation to total their ashed or chemical extraction weights (r=0.99, 0.93, 0.99 respectively). PIXImus uses a lower x-ray energy than that used for peripheral densitometry in humans in order to achieve contrast in the extremely low density bone. Excellent precision of BMD and %Fat makes PIXImus ideal for longitudinal studies.

With an image area of 80 mm x 65 mm, the PIXImus can image the entire body of most mice and the subcranial region of large ob\ob mice. The standard total body result focuses on the sub-cranial region improving sensitivity by excluding the inactive bone and tissue of the cranium. There are manual regions of interest (ROIs) for selected areas within the total body image, such as spine and femur. Researchers using the rat can image large portions of the animal and position ROIs over their area of interest (i.e. entire leg, spine, abdomen…) producing both bone and tissue results.

PIXImus is driven by single-key commands and a graphical user interface. A single function key performs an automated image acquisition and analysis. Subject results are printed in a clear, easy-to-understand format, and data are stored electronically in a globally accepted format.

Save Animals - A 10-week 'longitudinal' study of body composition - with weekly data points and a sample size of 10 - require 100 animals (10 sacrificed per week for 10 weeks). While the PIXImus only needs 10 animals to be imaged weekly, in true longitudinal fashion, saving 90 animals.

Save Time - Short-term time savings with PIXImus are obvious - the PIXImus needs only 5 minutes to acquire and analyze bone and tissue results while chemical extraction requires ~1 man-hour (homogenizing, scraping, cleaning, weighing, drying, chemical extraction, more weighing….). Longer-term savings are just as dramatic with chemical extraction's duration requiring days of drying and ashing time, meanwhile, the PIXImus is complete in 5 minutes. Yes, with PIXImus, you can have your data TODAY!

Save Money - The PIXImus saves your precious grant moneys with less animals and labor requirements as described above. But look deeper. Fewer animals require less cages, space, animal handling labor, food, chemicals, lab equipment…saving substantial research dollars and streamlining your operation.

Improve Confidence - Sufficient time and animals are saved with the PIXImus that it is both time- and cost-efficient to double, or even triple, the sample size of most any study. Larger sample sizes mean more robust statistics that please reviewers to get data published and/or products to market faster.

1 Nagy TR, Clair AL Precision and Accuracy of Dual-Energy X-ray Absorptiometry for Determining in Vivo Body Composition of Mice Obesity Research 2000; Vol. 8 No. 5: 392-398

PIXImus Mouse Densitometer
PIXImus's ultra-fast measurements and simple operation make it ideal for small animal research densitometry.

 

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