Gabriel Cornilescu
WELCOME!
Work Information
Projects
Biographical Information
Science links
Romanian links
Contact Information
Work Information
Lab of Prof. John Markley
Post-doctoral research on a protein-protein complex (HPr-IIAmtl, ~25kDa) structure by NMR
Supervisor: Dr. G. Marius Clore
Research on NMR methodologies applied to protein structure determination
Supervisor: Dr. Ad Bax
UMCP Supervisor: Prof. Gerald R. Miller
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Projects
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In progress: Determination of the NMR structures of two phytochrome chromophore-binding domains in both ground and light excited states
(collaboration with R. Vierstra's group)
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Measurement of site-specific protein backbone CSA tensors using six alignment media (collaboration with Ad Bax)
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Measurement of RDCs and refining an RNA structure with RDCs (collaboration with S. Butcher's group)
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Structure elucidation of a homodimeric protein (structural genomics target); other collaborations
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NMR structural study (including protein expression and purification) of a protein-protein complex:
Solution structure of the 25 kDa (IIAMannitol)-HPr Complex of the E. coli Phosphotransferase System.
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Detecting hydrogen bonds through scalar coupling
Identification of the hydrogen bonding network in a protein by measurement of the weak
(0.15-0.8 Hz) scalar couplings. Correlation with the hydrogen bond lengths (calculated from the X-ray structure).
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Protein backbone CSA(Chemical Shift Anisotropy) tensors
Measurement of backbone amide 1H, 15N and carbonyl 13C
CSA tensor components and orientation using weakly aligned proteins in a liquid crystalline medium.
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TALOS
(Torsion Angles Likeness Optimized by Shifts)
TALOS: A database based program for predicting protein backbone dihedral
angles using NMR chemical shifts and residue homology.
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Correlation betweeen one-bond Ca-Cb scalar couplings and protein backbone conformation
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Biographical Information
My C.V. ( pdf format, use
Acrobat Reader )
Bibliography
Course work (Biochemistry 801)
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Science links:
ISI Journal Abbreviations Index
Scientific Journals (some online)
Pub Med
Florida NMR Info Server
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Romanian links:
Romanian Photos by Dinu Lazar
Romanian Monasteries
Romanian Photo Galleries
Andrei Codrescu - Romanian born Writer
Romanian Poetry
U.S. State Department background page of Romania
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Contact Information
E-mail: gabrielc@nmrfam.wisc.edu
Web addresses:
http://webpages.charter.net/gabrielc
http://www.nmrfam.wisc.edu/NMRFAM/directory.html
http://spin.niddk.nih.gov/bax/people/cornilescu.html
Home address:
6 Rough Lee Ct
Madison, WI 53705
Phone:
608-442-7019
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Last Revised: Sept., 2008
